ABSTRACT
Objective To explore the significance of combined detection of procalcitonin(PCT)and C reactive protein(CRP)for clinical use of antibacterial agents in patients with pulmonary disease.Methods 130 cases of patients with pulmonary disease,from October 2012 to October 2014,were selected and randomly dividend into the observation group and control group,65 cases in each group.In the observation group,the utilization of antibacterial agents was decided according to serum levels of PCT and CRP,while in the control group that was based on the white blood cell count.Observation indexes,such as utilization of antibacterial agents, curative efficiency,length of stay and so on,were compared between the two groups after treatment.Results The length of antibac-terial agents use in the observation group[(8.6±0.4)d]was longer than that in the control group[(1 6.2±2.3)d],had statistically significant difference(P 0.05).While compared with the control group,the dual infection rate and length of stay decreased in the observation group,had sta-tistically significant difference(P <0.05).Conclusion Combined detection of PCT and CRP could guide the rational use of antibac-terial agents,effectively prevent the dual infection,and improve clinical curative effect.
ABSTRACT
This study was conducted to evaluate the applicability of 99mTc-2beta-[ N, N'-bis (2-mercaptoethyl) ethylenediamino]methyl,3beta(4-chlorophenyl)tropane(TRODAT-1) dopamine transporter(DAT) SPECT imaging in children with autism, and thus to provide an academic basis for the etiology, mechanism and clinical therapy of autism. Ten autistic children and ten healthy controls were examined with 99mTc-TRODAT-1 DAT SPECT imaging. Striatal specific uptake of 99mTc-TRODAT-1 was calculated with region of interest analysis according to the ratics between striatum and cerebellum [(STR-BKG)/BKG]. There was no statistically significant difference in semiquantitative dopamine transporter between the bilateral striata of autistic children (P=0.562), and between those of normal controls (p=0.573); Dopamine transporter in the brain of patients with autism increased significantly as compared with that in the brain of normal controls (P=0.017). Dopaminergic nervous system is dysfunctioning in the brain of children with autism, and DAT 99mTc-TRODAT-1 SPECT imaging on the brain will help the imaging diagnosis of childhcod autism.
Subject(s)
Child , Child, Preschool , Humans , Male , Autistic Disorder , Diagnostic Imaging , Metabolism , Brain , Diagnostic Imaging , Metabolism , Dopamine Plasma Membrane Transport Proteins , Metabolism , Organotechnetium Compounds , Tomography, Emission-Computed, Single-Photon , TropanesABSTRACT
Objective To reveal the relationship between the 5-HTTLPR and the Chinese Han nationality children with CA, compared the distribution of the 5-HTTLPR between the Han Chinese children with CA and healthy Han Chinese children ,and analyzed the association between the 5-HTTLPR and clinical symptoms of the Han Chinese children with CA. Methods Genomic DNAs of fifty subjects including 25 autistic children and 25 controls were extracted from blood samples. PCR amplification using Oligonucleotide primers flanking 5-HTTLPR was performed. Results ① Three kinds of alleles including the S (short) allele, the L (long) allele and the VL allele were found , and the 5-HTTLPR genotypes shown were S/S, L/L, S/L and L/VL. ② Allele frequencies did not differ significantly in patient groups in comparison with the control sample. No significant difference was identified between the observed 5-HTTLPR genotype distribution of the patient groups and control group. ③ The distribution of homozygous and heterozygous subjects between the two groups differed significantly. ④ The genotypes of the 5-HTTLPR polymorphism correlated significantly with the Body Movement Factor. ⑤ The allele frequency of healthy Han Chinese population and that of healthy Japanese population were similar. The frequency of S allele in not only autistic subjects but also healthy children in this study was considerably more than that in Caucasians and the frequency of L allele in our subjects decreased correspondingly. Conclusion ① A significant difference in the allele frequency between the Han Chinese and Caucasian populations was found. ② The genotypes of the 5-HTTLPR polymorphism correlated significantly with the Body Movement Factor of the patients. ③ The homozygote and the L allele were positively relevant to CA and they might be the risk factors of CA. The heterozygote and the S allele were negatively relevant to CA and they might be the protective factors of CA.
ABSTRACT
Objective: To reveal the relationship between the 5-HTTLPR and the Chinese Han nationality children with CA, compared the distribution of the 5-HTTLPR between the Han Chinese children with CA and healthy Han Chinese children, and analyzed the association between the 5-HTTLPR and clinical symptoms of the Han Chinese children with CA. Methods: Genomic DNAs of fifty subjects including 25 autistic children and 25 controls were extracted from blood samples. PCR amplification using Oligonucleotide primers flanking 5-HTTLPR was performed. Results: Circled digit one Three kinds of alleles including the S (short) allele, the L (long) allele and the VL allele were found, and the 5-HTTLPR genotypes shown were S/S, L/L, S/L and L/VL. Circled digit two Allele frequencies did not differ significantly in patient groups in comparison with the control sample. No significant difference was identified between the observed 5-HTTLPR genotype distribution of the patient groups and control group. Circled digit three The distribution of homozygous and heterozygous subjects between the two groups differed significantly. Circled digit four The genotypes of the 5-HTTLPR polymorphism correlated significantly with the Body Movement Factor. Circled digit five The allele frequency of healthy Han Chinese population and that of healthy Japanese population were similar. The frequency of S allele in not only autistic subjects but also healthy children in this study was considerably more than that in Caucasians and the frequency of L allele in our subjects decreased correspondingly. Conclusion: Circled digit one A significant difference in the allele frequency between the Han Chinese and Caucasian populations was found. Circled digit two The genotypes of the 5-HTTLPR polymorphism correlated significantly with the Body Movement Factor of the patients. Circled digit three The homozygote and the L allele were positively relevant to CA and they might be the risk factors of CA. The heterozygote and the S allele were negatively relevant to CA and they might be the protective factors of CA.
ABSTRACT
BACKGROUND: There are less researches on the relationship of parents'feeding behavior with nourishing and developing status of infants.OBJECTIVE: To study the relationship between the parents' feeding behavior and the nourishing and developing status of infants.DESIGN: A cross-sectional study.SETTING: Center of Maternal and Children' s Health,the First Hospital of Xi'an Jiaotong University.PARTICIPANTS: The study was carried out during January to December in 2002,at the Center of Maternal and Children' s Health,The First Hospital of Xi'an Jiaotong University. A total of 346 infants,aged 0 to 18 months old,were selected from the Fuping county and Chengcheng county of Weinan area by using the stratified duster sampline method. Inclusive criteria: infants with the gestation period between 37 to 42 weeks,without obvious diseases,no congenital abnormality; Exclusive criteria: infants with congenital disease or abnormality. Totally 324 infants,who were in accordance with the above criteria,were divided into 5 groups according to their month age.METHODS: The nursing persons of the infants were called at their houses,and the self-designed "Investigation Tables on Infant's Nutrition"were filled out.MAIN OUTCOME MEASURES: ① Status of slight malnutrition of infants of different month ages; ② Status of nutrition and development of infants,within 4 months, with different feeding behaviors; ③ Effects of beginning time,quality and frequency of complementary food on the nourishing and developing status of infants.RESULTS: In the first 4 months after birth,the rate of breast-feeding was high and the nourishing status of the infants was good. But the nourishing and developing status of infants became comparatively worse after 4 months age,because of inappropriate complementary food. As compared the slight malnutrition infants with normal infants,there were significant differences in the beginning time and kinds of complementary food(P<0.01).CONCLUSION: There is close relationship of the feeding behaviors with the nourishing and developing status of the infants.